Which of the following factors is least likely to worsen acne?

Drinking 3-5 glasses of wine a week is the factor least likely to worsen acne due to the absence of direct correlation between moderate alcohol consumption and the development or exacerbation of acne. While excessive alcohol can lead to dehydration and inflammatory responses in the body, moderate wine consumption does not trigger the same level of hormonal changes, oil production, or other acne-related factors that are more closely associated with skin issues.

In contrast, the other factors listed have been implicated in worsening acne. Fabric softeners can leave residues on clothing that may irritate the skin, and certain foods high in table salt can lead to dehydration and a potential imbalance in skin hydration. Working the night shift can disrupt sleep patterns and the body's circadian rhythm, leading to increased stress levels and hormonal fluctuations that are known to influence acne development.